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Mounjaro vs Ozempic: Which Weight Loss Injection Is Right for You?
Tirzepatide's dual GIP and GLP-1 receptor activity has demonstrated superior efficacy over semaglutide in trials, with SURPASS-2 showing an average HbA1c reduction of 2.3% versus 1.86% with semaglutide.
BSC, MB, BCHIR, DLO, DRCOG, MRCGP
GMC:
Introduction
Both are at the forefront of the weight loss revolution, but which is right for you? From mechanisms to outcomes and side effects to cost, we break down everything UK patients need to know before they make their decision on their perfect injectable option.
Mounjaro is a new injectable drug with tirzepatide, a dual-action medication made to treat type 2 diabetes and now increasingly being used for chronic weight management. The difference is that while conventional GLP-1 agonists only affected the GLP-1 receptor, Mounjaro acts on GIP (glucose dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. This provides an unconventional way to enhance insulin secretion, slow digestion, and curb appetite.
Ozempic is a more established medicine, used in the UK and around the world to treat type 2 diabetes. It has semaglutide, a GLP-1 receptor agonist that increases satiety, slows stomach emptying and helps your body regulate blood sugar.
Ozempic also was embraced off label for weight loss, but Wegovy (which has a higher dose of semaglutide) is officially approved to help manage weight in overweight adults.
Mechanism of Action: GLP-1 vs Dual GIP/GLP-1 Agonist
Both drugs act to suppress appetite, curb cravings, and enable people to eat less, all of which are critical for significant weight loss. The GIP part of Mounjaro also has a weight-reducing effect (belly fat in particular) and seems to enhance fat metabolism.
So, which one enables you to lose more weight?
These are real-world data and trial averages. Results will be different to each person, depending on diet, lifestyle and if the the patient has diabetes.
This is a clear win for tirzepatide especially in non-diabetic patients.
A comparing tirzepatide to semaglutide found Mounjaro users shed significantly more fat and waist circumference than their Ozempic counterparts. The combined action of the two hormones appears to be more beneficial when it comes to visceral fat, which is why it is the better pick for those with a higher body fat percentage.
These two meds can have mild to severe gastrointestinal disease side effects especially when you first start taking them or when your dose is increased:
Side effects are usually mild and temporary, getting better after a few weeks.
The majority of UK patients find both drugs well tolerated. But, Mounjaro may take longer to get used to as its appetite plays effects are stronger. An initial low dose with a gradual increase is an effective way to minimize side effects.
Mounjaro:
Ozempic:
Treatment is priced per clinic, dosage and package of consultations. Both are prescription only and subject to medical assessment.
Ozempic can be on the NHS for diabetes, but not for weight loss. Wegovy (an alternative to semaglutide) is already given to NHS patients, but strict rules apply.
The majority of UK health insurers do not cover for weight loss drugs such as Mounjaro or Ozempic. These drugs have traditionally been seen as cosmetic or lifestyle treatments, and so they are only covered by insurance if they are prescribed to treat a medical condition like type 2 diabetes.
However, there are exceptions. Most , health insurer Vitality became the first in the UK to offer discounts on weight-loss drugs, including Mounjaro and Wegovy (semaglutide), for those with a BMI of 35 and above, and with related health conditions. Certain drugs Members can get a discount of up to 20% on these medications for a year, as well as coverage for a dietitian.
A number of UK online pharmacies are currently providing the medicines via a remote health body consultation. You fill out an online questionnaire and consult with a pharmacist or clinician, typically by video call to confirm that you are eligible before the prescription is filled.
The most recent from the General Pharmaceutical Council (GPhC), state that processes have been
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