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Polynucleotide Treatment

Polynucleotide treatment by GMC Specialist Register plastic surgeons. Salmon-DNA bio-stimulator for skin regeneration, particularly effective for under-eye skin quality. From £595 single, £1,595 course of 3. CQC-regulated Baker Street clinic.

Polynucleotide Treatment at Centre for Surgery, London

Polynucleotide treatment in summary: A DNA-derived bio-stimulator injectable that drives skin regeneration at the cellular level — stimulating fibroblasts to produce new collagen and elastin. Polynucleotides are typically derived from purified salmon DNA. This is one of the two main skin booster pathways at Centre for Surgery (alongside Profhilo). Standard protocol: 3 sessions, 3 weeks apart. Best results visible 8–12 weeks after the third session, lasting 9–12 months. Performed by GMC Specialist Register plastic surgeons at Centre for Surgery. From £595 single session or £1,595 for the course of 3. CQC-regulated clinic.

Particular indications for polynucleotides:

What polynucleotides don’t do:

The clinical position: Polynucleotides have a meaningfully better safety profile than structural facial filler — the superficial dermal injection layer is away from major vessels, the volumes are small, and the bio-stimulation mechanism produces gradual rather than mechanical changes. The plastic surgeon credential matters most for honest patient selection, accurate under-eye assessment (distinguishing skin quality concerns from hollowing or fat bagging), and integration with the wider rejuvenation pathway.

Reversibility note: Unlike HA-based skin boosters, polynucleotides cannot be reversed with hyaluronidase — they’re not HA-based. They’re metabolised naturally by the body over months. Patient selection therefore matters more, which is why surgeon-led consultation is the model we use.

Related content at Centre for Surgery:

What Are Polynucleotides?

Polynucleotides are chains of nucleotides — the building blocks of DNA. The polynucleotides used in cosmetic skin treatment are DNA fragments derived from purified salmon DNA, chosen specifically because salmon DNA’s structure is biologically similar to human DNA.

The choice of salmon DNA isn’t arbitrary. Polynucleotide treatments require DNA fragments that:

The DNA is extracted from salmon trout sperm cells, then put through a multi-stage purification process that removes all proteins and other biological components, leaving only sterile DNA fragments. The result is a clear, viscous gel that’s biocompatible, CE-marked for cosmetic use, and free of fish proteins (the components that typically cause fish allergies).

The plastic surgeon selects the appropriate product based on your specific concerns and treatment plan.

When polynucleotides are injected into the dermis, they act as molecular signals that:

The result is biological skin regeneration. The skin produces more of its own structural and hydration components rather than receiving them mechanically from outside. This is why polynucleotides take longer to show full effect (8–12 weeks after the third session) but produce changes that persist beyond the product’s metabolic clearance — what’s been built (new collagen and elastin) remains in the skin even after the polynucleotide molecules themselves have been cleared.

For the broader skin booster category context, see the . For comparison with the alternative HA-based pathway, see .

Benefits of Polynucleotide Treatment

Polynucleotides produce gradual, cumulative skin quality improvement rather than dramatic immediate change. Patients typically describe results as looking "fresher" or "less tired" rather than "treated" — particularly noticeable around the eyes, where polynucleotides have their strongest effect.

This is one of polynucleotides’ most distinctive benefits. The under-eye region has thin skin where texture concerns dominate over volume concerns. Polynucleotides drive collagen production that thickens and improves under-eye skin quality — addressing the texture, fine line, and pigmentation contributions to "dark circles" that filler can’t address. For under-eye hollowing specifically, is appropriate; combination treatment is common.

Cumulative sun exposure causes structural skin damage — collagen breakdown, uneven pigmentation, fine surface lines, leathery texture. Polynucleotides drive collagen regeneration that addresses these underlying structural changes, going beyond what surface-only treatments achieve.

The bio-stimulation effect over weeks produces gradually improving skin texture — smoother to the touch, more even visually, with better surface light reflection.

For mild post-acne surface irregularity, polynucleotides drive surface remodelling that can produce meaningful texture improvement. Important caveat: deep acne scars (boxcar, ice-pick, rolling) typically need with laser resurfacing or surgical revision — polynucleotides are an adjunct rather than a primary treatment.

The biological mechanism of polynucleotides is fundamentally different from "topping up" treatments. The skin produces more of its own collagen, elastin, and HA — the changes are cellular and persist beyond the product’s metabolic clearance.

The collagen and elastin production stimulated over the course produces mild firming and elasticity improvement. Less dramatic than surgical lifting, but meaningful for early skin laxity.

Polynucleotides have demonstrable anti-inflammatory properties at the local tissue level — useful for patients with skin inflammation, mild irritation, or post-procedural skin recovery.

The combination of improved cellular metabolism, vascularisation, and hydration produces visibly improved skin glow over the course — patients commonly report being told they look healthier or rested.

Polynucleotides treat the face, under-eyes specifically, neck, décolletage, hands, stomach, arms, and legs — broad versatility across the body for skin quality concerns.

Polynucleotides combine well with HA fillers, anti wrinkle injections, Profhilo, laser treatments, and surgical rejuvenation — making them a flexible component of comprehensive treatment plans.

The purification process removes all proteins, leaving only DNA fragments. This means most patients with fish allergy can theoretically receive polynucleotides — but as a cautious clinical position, we recommend Profhilo or other alternatives for any patient with known fish allergy. The marginal benefit doesn’t justify the small risk.

The cumulative, gradual nature of polynucleotide treatment means results don’t look "done". Patients commonly report subtle compliments rather than direct identification of treatment — the aesthetic ideal of natural rejuvenation.

How Polynucleotide Treatment Works

Polynucleotides work through a different mechanism from any other injectable in cosmetic medicine. Understanding the mechanism helps set realistic expectations about what polynucleotides can do (and the timeline over which they work).

The injection technique places polynucleotides in the superficial dermis — the skin layer where fibroblasts (the cells that produce collagen, elastin, and HA) are located. Multiple small papular injections deliver evenly distributed product across the treatment area.

Salmon-derived DNA fragments are biologically similar to human DNA. Human fibroblasts recognise these polynucleotide fragments as familiar molecular signals — not foreign material to be rejected. This biological compatibility is why polynucleotides produce a regenerative response rather than an inflammatory or immune response.

In response to polynucleotide signalling, fibroblasts increase their synthetic activity. They produce more:

The increase in synthetic activity is sustained over weeks to months as the polynucleotides remain in the tissue and continue signalling.

The new collagen and elastin produced by activated fibroblasts gradually remodels the existing skin tissue. Old, damaged collagen is replaced by new, healthier collagen. The result is structural skin renewal — not just on the surface, but at a tissue level.

In addition to collagen production, polynucleotides improve local cellular metabolism and tissue oxygenation. The vascularisation in the treated area improves, supporting healthier cell turnover and better long-term skin quality.

Over 9–12 months, the polynucleotides themselves are metabolised by the body and cleared. But the new collagen, elastin, and HA they stimulated remain — which is why polynucleotide effects persist even after the product has been cleared.

The standard polynucleotide protocol is 3 sessions, 3 weeks apart. The biological reasoning:

Skipping sessions or extending intervals produces sub-optimal results. The protocol exists because clinical evidence supports this specific schedule.

Patients sometimes ask why polynucleotides take 4–5 months from start to peak result. The answer is biological:

This contrasts with HA filler (immediate visible volume) or anti wrinkle injections (visible muscle relaxation within days). Polynucleotides change the skin’s biology, which takes time but produces persistent results.

What Polynucleotide Treatment Targets

Polynucleotides are particularly suited to specific skin quality concerns. Below are the main indications, with notes on whether polynucleotides are the best treatment or whether another approach would deliver better results.

Best treatment: Polynucleotides

Why it works: The thin under-eye skin shows texture concerns, fine lines, and pigmentation more readily than other facial areas. Polynucleotides specifically improve the structural skin quality — thickening, smoothing, and reducing the contributing factors to "dark circles" that aren’t related to hollowing.

Important distinction: Many patients ask for "under-eye filler" — but the appropriate treatment depends on the cause. Hollowing → . Texture/skin quality → polynucleotides. Fat bagging → . Many patients have combinations and need combined treatment.

Best treatment: Polynucleotides (often combined with laser)

Why it works: Cumulative UV exposure causes structural collagen damage, uneven pigmentation, and fine surface lines. Polynucleotides drive collagen regeneration that addresses the structural component. Combined with for surface-layer photo-damage, this produces layered photo-damage repair.

Best treatment: Polynucleotides as adjunct

Why it works: Polynucleotides drive surface remodelling that improves mild surface irregularity from past acne.

Important caveat: Deep acne scars (boxcar, ice-pick, rolling) need with laser, surgical revision, or other primary scar treatment. Polynucleotides are a quality-improvement adjunct rather than a primary scar treatment.

Best treatment: Polynucleotides

Why it works: Patients seeking biological skin renewal — rather than mechanical fillers or surface-only treatments — benefit from polynucleotides’ fibroblast activation and collagen-stimulation mechanism.

Best treatment: Polynucleotides

Why it works: For patients planning or , polynucleotides used pre-operatively can optimise under-eye skin quality, supporting better surgical results. Used post-operatively, they support skin recovery and maintain results.

Best treatment: Polynucleotides (or Profhilo, depending on dominant concern)

Why it works: Mild skin laxity in patients with photo-damage component responds particularly well to polynucleotides because both texture and elasticity improve.

Important caveat: Significant laxity needs ; widespread mild laxity often does better with .

Best treatment: Polynucleotides or Profhilo, depending on dominant concern

Polynucleotides for: Photo-damaged texture, deeper skin quality concerns

Profhilo for: Hydration-driven laxity, crepey texture

Best treatment: Polynucleotides as adjunct

Why it works: The anti-inflammatory effects of polynucleotides can support skin recovery after laser treatments, surgery, or in patients with chronic mild skin inflammation.

Who Is Suitable for Polynucleotide Treatment?

Adults aged 18+ are eligible. Suitability is confirmed at face-to-face consultation with the plastic surgeon, who tells patients honestly when polynucleotides aren’t the right treatment.

Known fish allergy. Polynucleotides are derived from salmon DNA. Although the manufacturing process purifies the product to remove proteins, residual sensitivity is theoretically possible. Our cautious clinical position: we don’t use polynucleotides in patients with known fish allergy. We recommend (HA-based, non-fish-derived) or other alternatives. The marginal clinical benefit of polynucleotides over alternatives doesn’t justify the small risk of an allergic reaction.

We tell patients directly when polynucleotides aren’t the right treatment. Common scenarios where we redirect:

The mandatory two-week cooling-off period applies — you book consultation, then book treatment minimum 14 days later.

Polynucleotides Compared with Other Skin Treatments

Polynucleotides occupy a specific niche in cosmetic skin treatment. Understanding how they compare with alternatives helps clarify when polynucleotides are the right choice and when another treatment would deliver better results.

Polynucleotides work at the dermal level via bio-stimulation; works at the epidermal/dermal level via thermal injury to drive renewal. Both can address photo-damage and texture concerns. Common combination: laser for surface-layer renewal plus polynucleotides for deeper bio-stimulation, with the surgeon designing the appropriate protocol and sequencing.

In practice, polynucleotides rarely stand alone. Most patients benefit from combination treatment — polynucleotides for skin quality alongside structural filler, anti wrinkle, laser, or surgical work as needed. The plastic surgeon designs the combination at consultation based on your specific concerns and goals.

The Polynucleotide Treatment Procedure

Each polynucleotide session takes 30–45 minutes total — the injection itself takes 15–20 minutes once numbing is complete. The full standard protocol is 3 sessions, 3 weeks apart.

A face-to-face consultation with the GMC Specialist Register plastic surgeon is required before any treatment. The consultation includes:

Each session follows the same protocol:

The 3-week interval matters:

A follow-up review 2 weeks after session 3 is included in the course price. The surgeon assesses early response, discusses any concerns, and confirms timing for the longer-term peak result assessment.

After the foundational 3-session course, maintenance options:

Polynucleotide Aftercare and Recovery

Recovery in summary: Minimal downtime. Resume work and most normal activities the same or next day. The small papular bumps at injection points resolve within 24–48 hours. Avoid pressure on the treated area for 24 hours, makeup for 12 hours, vigorous exercise for 48 hours, and intensive facial treatments (peels, laser) for 2 weeks. Possible bruising at some points may take 5–7 days to resolve.

Polynucleotides have a generally favourable safety profile — but problems can still occur. Contact us on if you experience:

Important reversibility note: Polynucleotides cannot be dissolved with hyaluronidase because they’re not HA-based. They’re metabolised naturally by the body over months. This is why patient selection at consultation matters — once injected, polynucleotides remain until natural clearance.

Polynucleotide Treatment Cost in London — Plastic Surgeon-Led Pricing

Polynucleotide treatment at Centre for Surgery is £595 for a single session or £1,595 for the course of 3 (the standard protocol). Pricing reflects the GMC Specialist Register plastic surgeon credential and the integrated treatment planning across the full rejuvenation pathway.

The course of 3 represents the recommended pathway and offers approximately £190 saving versus single-session pricing. We recommend the full course for first-time polynucleotide patients.

For patients combining polynucleotides with other treatments — particularly common for under-eye applications:

Every quote at Centre for Surgery includes:

There are no hidden charges. The price quoted at consultation is the price you pay.

Standard nurse-injector polynucleotide pricing in London ranges £250–£400 per session (£700–£1,200 for course of 3). Our pricing reflects:

For multi-session courses or combination treatments, Chrysalis Finance offers payment plans. 0% APR options are available subject to status, with longer terms at variable rates.

Indicative monthly costs at 0% APR over 12 months:

Full finance details are on our , or speak to a patient coordinator on .

Why Choose Centre for Surgery for Polynucleotide Treatment

Polynucleotides are a relatively low-risk treatment compared with structural facial filler — but the clinical decisions around them are nuanced. The reason to choose plastic-surgeon-led polynucleotides at Centre for Surgery isn’t primarily about technical safety; it’s about getting the right treatment for your specific concerns, with honest assessment of when polynucleotides are the right answer and when they aren’t.

Every polynucleotide treatment at Centre for Surgery is performed by a plastic surgeon on the GMC Specialist Register — the same surgeon who would perform your , , , or other facial rejuvenation surgery. Surgeon-led delivery brings particular advantages for polynucleotides: rigorous patient selection, accurate under-eye assessment (the most-demanding judgment in polynucleotide consultation), treatment combination planning, and integration with the wider rejuvenation pathway.

We offer the complete range: skin boosters (, , polynucleotides), , , , , and surgical rejuvenation including upper and lower blepharoplasty, facelift, and brow lift. The consultation isn’t biased toward polynucleotides because we offer the full pathway.

Polynucleotides are one of the areas where careful patient selection matters most. Common scenarios where we recommend a different treatment:

We don’t sell you treatment that won’t deliver what you’re looking for.

The under-eye region is the strongest indication for polynucleotides — and the area where consultation precision matters most. Patients consulting for "under-eye treatment" may have any of: skin quality concerns (where polynucleotides help), tear trough hollowing (where filler helps), fat herniation (where surgery helps), or combinations. Plastic-surgeon-led consultation reliably distinguishes these and recommends the appropriate treatment or combination.

Polynucleotides are derived from salmon DNA. Although the manufacturing purifies the product, residual fish allergy sensitivity is theoretically possible. Our cautious clinical position: we don’t use polynucleotides in patients with known fish allergy, and we always ask. The marginal benefit of polynucleotides over doesn’t justify the small risk of an allergic reaction. Surgeon-led consultation ensures this screening happens reliably.

We treat polynucleotides as a course (3 sessions, 3 weeks apart) rather than a one-off appointment. Single-session polynucleotide pitches produce sub-optimal results. We design the full protocol at consultation, price it transparently, and deliver it as a coherent treatment plan.

Polynucleotides rarely stand alone — most patients benefit from combination with tear trough filler (for under-eye), SmoothEye laser, Profhilo, or surgical work. We design integrated plans with the surgeon executing the full plan rather than the patient coordinating across multiple practitioners.

Centre for Surgery is a private clinic on Baker Street, London. The same clinical governance standards required of any private hospital apply at our clinic.

We use CE-marked polynucleotide products — most commonly Plenhyage XL, with alternative products available. The plastic surgeon selects the appropriate product based on your specific concerns and treatment plan.

The clinic is at 95–97 Baker Street, Marylebone, London W1U 6RN, a short walk from Baker Street tube station (Jubilee, Metropolitan, Circle, Hammersmith & City, and Bakerloo lines).

A face-to-face consultation with the plastic surgeon is required before any treatment.

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Address: 95–97 Baker Street, Marylebone, London W1U 6RN

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Finance options are available from , including 0% APR, subject to status.

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Our purpose-built private hospital at Baker Street, Marylebone is independently regulated and inspected by the Care Quality Commission (CQC), which awarded us a Good rating — a standard very few cosmetic surgery facilities in the UK achieve. We use TIVA (Total Intravenous Anaesthesia) as standard, the safest and most advanced form of anaesthesia available for day case surgery.



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Marylebone

London

W1U 6RN

Mon – Sat, 9am – 6pm

Saturday consultations available